The burgeoning interest in in situ multiplexed gene expression profiling technologies has opened new avenues for understanding cellular behavior and interactions. In this study, we present a ...

Annotation of newly-sequenced genomes frequently includes genes, but rarely covers important non-coding genomic features such as the cis-regulatory modules—e.g., enhancers and silencers—that regulate ...

Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. The human hepatic lectin asialoglycoprotein receptor (ASGR) is selectively expressed on ...

Encoding of sensory information in our eyes and ears builds on specialized ribbon synapses of sensory cells. Elucidating the molecular underpinning of their fascinating structure and function is an ...

Preparatory states within the motor cortex play a critical role in selecting an appropriate action in response to sensory input, dependent on the context.

It is currently impossible to non-invasively assess cerebellar cell structure during early development. Here we propose a novel approach to non-invasively and longitudinally track cell-specific ...

Endothelial and skeletal muscle lineages arise from common embryonic progenitors. Despite their shared developmental origin, adult endothelial cells (ECs) and muscle stem cells (MuSCs) (satellite ...

Chunxiao Li, postdoctoral researcher in vertebrate paleontology, University of Chinese Academy of Sciences, Beijing, China, shares her experience of publishing a Reviewed Preprint with eLife.

Our cells rely on a large set of genes, each one fulfilling a particular task. But what happens if there is a need for a gene to carry out a new task? Famously, evolution is a tinkerer and rather than ...

The structural integrity of the sperm is crucial for male fertility, defects in sperm head-tail linkage and flagellar axoneme are associated with acephalic spermatozoa syndrome (ASS) and the multiple ...

Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, 100193, P. R. China Berry Genomics Corporation, Beijing, 100015, P. R ...

A computational model of skeletal muscle regeneration reveals complex interplay of cytokines, angiogenesis, and cell behaviors, predicting that synergistic cytokine perturbations enhance skeletal ...