Faster Cleanup While Awake? In the frontal cortices of mice anesthetized with ketamine-xylazine (top) or sleeping (middle), an injected dye clears more slowly than in awake mice (bottom).

Huddle Up! In APP/PS1 controls (left), astrocytes (green) and microglia (brown) form a wide glial net around plaques. Without Plexin-B1 to enforce cell spacing (right), glia crowd together and around ...

Going Nuclear. In cortical tissue from healthy people (top), RNA-binding proteins SFPQ (red) and NONO (green) form puncta in nuclei (blue). In DLB cortex (bottom), the aggregates were larger and more ...

Even before the first flicker of symptoms surface in a person who carries a pathogenic frontotemporal dementia mutation, signs of the disease can be found in their blood, in the form of neurofilament ...

Over the past three decades, the incidence of dementia has been declining in the U.S. and Europe. One reason might be that ...

Other 4R tau tracers are in development. Vasdev and colleagues Chet Mathis at the University of Pittsburgh and Samuel ...

The findings suggest that turning down the type I interferon response explains part of the protection afforded by ApoE3-R136S, implying that some of the benefits of this rare mutation might be ...