Would this Trojan horse work in vivo? The scientists loaded BI-hTFR1 viruses with luciferase genes, then added them to primary and cultured human brain endothelial cells. These cells shunt transferrin ...

Little by little, amyloid immunotherapy is finding more use at U.S. clinics, with procedures in place to smooth patients’ experience. Two new developments may simplify things. First, Eisai and Biogen ...

APOE4 is the strongest risk factor for Alzheimer’s disease. APOE4 homozygosity was recently identified as a distinct, highly penetrant form of AD. However, a small percentage of APOE4 homozygotes live ...

As the paper stresses appropriately, there is sufficient and rigorous postmortem evidence that the LC accumulates AD tau before the entorhinal cortex (EC-Braak 1 area), and that the tau burden in LC ...

For 30 years, APOE4 has ranked as the strongest genetic risk factor for Alzheimer’s disease, with two copies boosting the odds up to 15-fold. Now, scientists make the case that people with two APOE4 ...

More AD tests are entering the market. For example, the laboratory services provider Labcorp, based in Burlington, North Carolina, recently announced that it's now offering a blood test for ...

The Alzheimer’s risk gene phospholipase C-γ2 has been thought to act mainly in microglia. Now, in a May 1 preprint on bioRxiv, researchers led by Jean-Charles Lambert, Julie Dumont, and Julien Chapuis ...

Over the last few decades, evidence has emerged to peg the sortilin-related receptor, SORL1, as a risk factor for Alzheimer’s disease and even as the fourth gene for familial AD. SORL1 helps traffic ...